Reserve concomitant prescribing of such drugs in patients for whom other treatment options are inadequate. Limit dosages and durations on the minimum expected. Keep an eye on carefully for signs of respiratory depression and sedation.

etravirine will lower the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of fentanyl with CYP3A4 inducers could lead on into a lessen in fentanyl plasma concentrations, not enough efficacy or, possibly, improvement of a withdrawal syndrome within a individual who's got designed Bodily dependence to fentanyl.

If coadministration of CYP3A4 inhibitors with fentanyl is necessary, keep an eye on patients for respiratory depression and sedation at Recurrent intervals and consider fentanyl dose adjustments until eventually stable drug effects are attained.

olanzapine/samidorphan decreases effects of fentanyl by pharmacodynamic antagonism. Contraindicated. Samidorphan elicits opioid antagonistic effects and boosts risk of precipitating acute opioid withdrawal in patients dependent on opioids.

Monitor Carefully (one)omaveloxolone will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

Watch Carefully (1)nevirapine will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Coadministration of fentanyl with CYP3A4 inducers could lead on to a decrease in fentanyl plasma concentrations, not enough efficacy or, quite possibly, progress of a withdrawal syndrome within a affected person who has produced Actual physical dependence to fentanyl.

Contraindicated (1)olanzapine/samidorphan decreases effects of fentanyl by fentanyl in epidurals pharmacodynamic antagonism. Contraindicated. Samidorphan elicits opioid antagonistic effects and increases risk of precipitating acute opioid withdrawal in patients dependent on opioids.

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Major - Use Alternate (one)fosphenytoin will lessen the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of fentanyl with CYP3A4 inducers may lead into a reduce in fentanyl plasma concentrations, lack of efficacy or, probably, improvement of a withdrawal syndrome inside a patient who may have formulated Bodily dependence to fentanyl.

isavuconazonium sulfate will raise the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.

If coadministration of CYP3A4 inhibitors with fentanyl is important, keep track of patients for respiratory depression and sedation at Repeated intervals and consider fentanyl dose adjustments until eventually stable drug effects are accomplished.

istradefylline will improve the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.

diazepam buccal and fentanyl the two increase sedation. Keep away from or Use Alternate Drug. Limit use to patients for whom substitute treatment options are insufficient

Coadministration of encorafenib with delicate CYP3A4 substrates may perhaps bring about elevated toxicity or lowered efficacy of these agents.